77 New Cases Of Hepatitis C Identified In Las Vegas
Nevada health officials said Thursday that they had identified 77 new cases of hepatitis C among patients treated at a Las Vegas endoscopy practice, in one of the countryâ??s largest outbreaks of the liver disease. The officials had previously
EMEA Provides Guidance on Chronic Hepatitis C Trials
The primary endpoint for confirmatory efficacy studies of treatments for chronic hepatitis C (CHC) should be sustained virological response (SVR), according to a draft guideline from the European Medicines Agencys Committee for Medicinal Products for
May is National Hepatitis Awareness Month
, which was first designated by the Centers for Disease Control and Prevention (CDC) in 2001. This is an important opportunity to help raise awareness about viral hepatitis in this country. With as many as 5 million Americans affected by chronic
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New Mexico Offers Free Hepatitis C Hotline
Finally being recognized as the widespread, public health problem that it is, the New Mexico Department of Health has taken a giant step forward to help people with Hepatitis C. By launching a new, toll-free phone number, locals concerned about...
Highly Effective Against HCV Genotype 1
When tested on people with Hepatitis C genotype 1, R7128 proved to be an effective addition to combination therapy after just four weeks' time. In addition to its anti-viral effect, polymerase inhibitor R7128 received good marks for safety and minimal...
Investigational Drug Beats Standard Therapy in Hepatitis C Study
A Phase IIa trial investigating triple combination therapy with PEGASYS, COPEGUS and Roche's investigational drug R1626, demonstrated a higher response rate than traditional combination therapy alone. While R1626's effectiveness and high barrier to resistance makes it a top Hepatitis C...
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| Cirrhosis Symptoms and Signs
With obstruction to bile flow, jaundice, pruritus, and xanthelasma
become prominent features. Malnutrition is common secondary to anorexia,
fat malabsorption, and fat-soluble vitamin deficiency due to the
effects of reduced bile-salt excretion. A more dramatic presentation
is massive upper GI bleeding from esophageal varices secondary to
portal hypertension. The initial presentation may occasionally be
that of hepatocellular failure with ascites or portal-systemic encephalopathy.
A palpable, firm, liver with a blunt edge is typical, but at times
the liver is small and difficult to palpate. Cirrhotic nodules are
only occasionally palpable. Ascites may be present with portal hypertension
and splenomegaly, and a collateral venous circulation is evident.
Other clinical signs may suggest chronic liver disease, but none
is specific: muscle wasting, palmar erythema, Dupuytren's palmar
contractures, vascular vascular spiders (< 10 may be normal),
gynecomastia, parotid gland enlargement, hair loss, testicular atrophy,
and peripheral neuropathy.
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