Hepatitis C Information Central

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HEPATITIS NEWS

77 New Cases of Hepatitis Are Identified in Las Vegas
at 4:52 a.m. Nevada health officials said Thursday that they had identified 77 new cases of hepatitis C among patients treated at a Las Vegas endoscopy practice, in one of the countrys largest outbreaks of the liver disease. The officials had previously

Risk of Malignant Lymphoma Increased With Hepatitis C Infection
Extract not available.

77 New Cases of Hepatitis Are Identified in Las Vegas
Nevada health officials said Thursday that they had identified 77 new cases of hepatitis C among patients treated at a Las Vegas endoscopy practice, in one of the countrys largest outbreaks of the liver disease. The officials had previously identified

UPDATES AND COMMENTARY

Highly Effective Against HCV Genotype 1
When tested on people with Hepatitis C genotype 1, R7128 proved to be an effective addition to combination therapy after just four weeks' time. In addition to its anti-viral effect, polymerase inhibitor R7128 received good marks for safety and minimal...

Investigational Drug Beats Standard Therapy in Hepatitis C Study
A Phase IIa trial investigating triple combination therapy with PEGASYS, COPEGUS and Roche's investigational drug R1626, demonstrated a higher response rate than traditional combination therapy alone. While R1626's effectiveness and high barrier to resistance makes it a top Hepatitis C...

Hepatitis C Complications Helped by Maintenance Interferon
A four-year study confirms that low-dosage maintenance interferon therapy prevents disease progression in those with portal hypertension or cirrhosis from Hepatitis C....

Damage Scores for Liver Biopsy

Less Than

More Than

HISTOLOGY ACTIVITY INDEX (HAI - Knodell Score)
Periportal ± Bridging Necrosis	Score	Intralobular Degeneration and Focal Necrosis	Score	Portal Inflammation	Score	Fibrosis	Score
None	0	None	0	No portal inflammation	0	No fibrosis	0
Mild piecemeal necrosis	1	Mild (acidophilic bodies, ballooning degeneration and/or scattered foci of hepatocellular necrosis in 1/3 of lobules or nodules)	1	Mild (sprinkling of inflammatory cells in 1/3 of portal tracts)	1	Fibrous portal expansion	1
Moderate piecemeal necrosis (involves 50% of the circumference of most portal tracts)	3	Moderate (involvement of 1/3-2/3 of lobules or nodules)	3	Moderate (increased inflammatory cells in 1/3-2/3 of portal tracts)	3	Bridging Fibrosis (portal-portal or portal-central linkage)	3
Marked piecemeal necrosis (involves 50% of the circumference of most portal tracts)	4	Marked (involvement of 2/3 of lobules or nodules)	4	Marked (dense packing of inflammatory cells in 2/3 of portal tracts)	4	Cirrhosis	4
*Moderate piecemeal necrosis plus* bridging necrosis**	5	ReferenceKnodell RG, et al.
*Marked piecemeal necrosis plus* bridging necrosis**	6
Multilobular necrosis	10

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