Homeostatic Control of Angiogenesis: A Newly Identified Function
of the Liver?
Fig. 1. Schematic representation of plasminogen and
collagen XVIII and their cryptic fragments with angiogenesis
inhibitory activities. Plasminogen: The N-terminal and internal
fragments of angiostatin (gray boxes) include the first four of the
five disulfide-linked structures of plasminogen, known as kringle
structures. Collagen XVIII: The two N-terminal end variants of
human collagen XVIII have noncollagenous domains fo 493 (NC-493)
and 303 (NC-303) amino acids, respectively. Human hepatocytes
express the NC-493 variant at high levels. Both variants share the
C-terminal residues of the N-terminal NC domain (stippled
box), the collagenous domains (full line), the
noncollagenous interruptions (black boxes), and the
C-terminal noncollagenous domain of the molecule (horizontal
lines) containing endostatin (gray box).
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