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Basophilia, if absolute and of marked degree is a great clue to the presence of myeloproliferative disease as opposed to leukemoid reaction. Other causes of basophilia include allergic reactions, chickenpox, ulcerative colitis, myxedema, chronic hemolytic anemias, Hodgkin's disease, and status post-splenectomy. Estrogens, antithyroid drugs, and desipramine may also increase basophils.

Basopenia is not generally a clinical problem.

About Basophils:

The most aesthetically pleasing of all the leukocytes, the basophils are also the least numerous, the normal range of their count in peripheral blood being 0 - 200/µL. They are easily recognized by their very large, deep purple cytoplasmic granules which overlie, as well as flank, the nucleus (eosinophil granules, by contrast, only flank the nucleus but do not overlie it). It is tempting to assume that the basophil and the mast cell are the blood and tissue versions, respectively, of the same cell type. Actually it is controversial as to whether this concept is true or whether these are two different cell types.

The table below presents some of the contrasts between mast cells and basophils.

In active allergic reactions, blood basophils decrease in number, while tissue mast cells increase. This reciprocal relationship suggests that they represent the same cell type (i.e., an allergen stimulates the passage of the cells from the blood to the site of the allergen in the tissues). Some experiments with animals have also shown that mast cells are marrow-derived and are capable of differentiating into cells that resemble basophils. Conversely, some recent evidence suggests that basophils (as well as eosinophils) can differentiate from metachromatic precursor cells that reside among epithelial cells in the nasal mucosa

Without invoking religion or Alexander Pope ("Whatever is, is right," An Essay on Man, 1732-34) it is hard to see any useful role of the basophil/mast cell in human physiology. The mast cell is the essential effector of immediate (Type 1) hypersensitivity reactions, which produce only misery, dysfunction, and occasionally death for the hapless host.

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