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10-Year Follow-up After Interferon-alpha Therapy for Chronic Hepatitis C

table 1

table  1.   Clinical, Serum Biochemical, Histological, and Serological Features of Ten Patients With Chronic Hepatitis C Treated With Alpha Interferon
No. Clinical Features
Initial
Final
Follow-up (yr) Clinical Outcome
Resp Age (yr) Sex Source Genotype RNA ALT HAI RNA ALT HAI Liver RNA
1 SR 30 M IDU 1a + 376 11 <100 20 3 11 Asymptomatic
2 SR 27 M Tx 2a/2b + 460 8 <100 52 3   10 Asymptomatic
3 SR 37 M IDU 2a + 306 11 <100 21 1   11 Asymptomatic
4 SR 40 M Tx 3 + 272 11 <100 35 2   10 Asymptomatic
5 SR 29 M Tx 2a + 185 11 <100 23 0   10 Asymptomatic
6 NR 51 M IDU 1 + 219 12 1500 23 11 NA 13 HCC/OLT
7 NR 41 M Unknown 1b + 419 14 .18 × 106 181 12 NA 6 Died/Stroke
8 NR 62 F Tx 1b + 200 8 .049 × 106 248 16 + 11 Symptoms
9 NR 38 M Tx 1a + 148 17 >5 × 106 102 15 + 11 Symptoms
10 NR 46 M Tx 1b + 392 15 1.4 × 106 326 12 NA 11 Symptoms
Abbreviations: Resp, virological response; SR, sustained response; NR, non-response; IDU, injection drug use; Tx, transfusion; HAI, histology activity index score; HCC, hepatocellular carcinoma; OLT, orthotopic liver transplantation; NA, not available.

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