Hepatitis C Virus RNA Profiles in Chronically Infected
Individuals: Do They Relate to Disease Activity?
| table 3.
Maximum Changes of HCV RNA (Log genomes/mL) Observed in Serum
During Follow-up in HCV-Infected Patients |
|
|
Monthly Sampling
|
Yearly Sampling
|
No. of
Cases |
HCV-RNA Change
(mean ± SD) |
HCV-RNA Change
(range) |
No. of
Cases |
HCV-RNA Change
(mean ± SD) |
HCV-RNA Change
(range) |
|
| ALT profile |
| Normal ALT |
28 |
0.7 ± 0.3* |
0.2-1.4 |
10 |
0.8 ± 0.7 |
0.2-2.2 |
| Elevated ALT |
26 |
1.3 ± 0.7 |
0.3-3.1 |
12 |
1.0 ± 0.5 |
0.5-1.7 |
| Genotype |
| Genotype 1 |
38 |
1.0 ± 0.5 |
0.2-2.2 |
7 |
1.0 ± 0.6 |
0.4-1.9 |
| Genotype 2 |
14 |
1.1 ± 0.8 |
0.3-3.0 |
15 |
0.7 ± 0.5 |
0.2-1.8 |
| Genotype 3 |
2 |
2.4 ± 1.1 |
1.6-3.1 |
0 |
| Liver histology |
| Minimal changes |
2 |
0.3 ± 0.24 |
0.2-0.4 |
1 |
0.2 |
0.2 |
| Mild CH |
18 |
1.3 ± 0.8 |
0.3-2.2 |
7 |
1.3 ± 0.7 |
0.4-2.2 |
| Moderate CH |
16 |
1.2 + 0.9 |
0.3-3.1 |
4 |
1.2 + 0.5 |
0.7-1.8 |
| Severe CH |
1 |
1.6 |
1.6 |
0 |
 |
|
|
Abbreviation: CH = chronic hepatitis.
* vs P = .004. |
|
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Copyright © 1999
by the American Association for the Study of Liver
Diseases.
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|
