Hepatitis C Virus RNA Profiles in Chronically Infected
Individuals: Do They Relate to Disease Activity?
| table 1.
Histological Features Observed in Chronic HCV Patients in Relation
to Transaminase Profile and Viremia Levels |
|
|
Minimal
Changes |
Mild
CH |
Moderate
CH |
Severe
CH |
P |
|
| ALT pattern over 12 months |
| Normal ALT |
3 |
15 |
5 |
0 |
.012 |
| Fluctuating |
0 |
10 |
15 |
1 |
| HCV-RNA fluctuations |
 < 0.5 Log |
3/3 |
3/15 |
3/12 |
0 |
NS |
 0.5 Log |
0 |
12/15 |
9/12 |
1/1 |
|
NOTE. represents the difference between the
maximum and minimum value of HCV RNA measured over time in each
individual patient. 0.5 Log is considered the cut-off for the
intrinsic variability of the assay.
Abbreviations: CH, chronic hepatitis; NS, not significant. |
|
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by the American Association for the Study of Liver
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