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A Prospective, Community-Based Evaluation of Liver Enzymes in Individuals With Hepatitis C After Drug Use

table  1.   Correlates of Serial ALT Values Among HCV-Infected Individuals
Number ALT Not Elevated*
 % (n) 		ALT Elevated <50%
Visits % (n) 		ALT Elevated 50%
Visits % (n) 		ALT Always
Elevated % (n) 		P
Gender
  Male 789 34 (271) 22 (176) 23 (183) 20 (159)  
  Female 253 62 (157) 15 (39) 11 (28) 11 (29) .001
Age (yr)
  <41 551 37 (203) 20 (112) 23 (129) 19 (107)  
  41 491 46 (225) 21 (103) 17 (82) 17 (81) .002
Alcohol Usedagger
  Yes 665 38 (252) 22 (146) 21 (138) 19 (129)  
  No 377 47 (176) 18 (69) 19 (73) 16 (59) .012
Current IDUdagger
  Yes 629 44 (279) 20 (128) 21 (132) 14 (90)  
  No 413 36 (149) 21 (87) 19 (79) 23 (98) .001
HIV Negative 568 41.5 (236) 20.6 (117) 19.9 (113) 18 (102)  
HIV Positive
  CD4 >500 94 42.5 (40) 17.0 (16) 23.4 (22) 17.0 (16)  
  CD4 200-499  211 37.9 (80) 21.3 (45) 21.8 (46) 19.0 (40)  
  CD4 0-199  159 43.4 (69) 22.6 (36) 17.0 (27) 17.0 (27) >.10
Abbreviations: IDU, injection drug use; CD4 count expressed in cells/mL.
* ALT values drawn at intervals 6 mo. All individuals had at least 2, but no more than 5, measurements.
dagger Alcohol drinker defined as regular alcohol intake in 6 mo before visit.
dagger Current IDU defined as use of injection drugs in 6 mo before visit.

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