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Histopathology of the Liver in Children With Chronic Hepatitis C Viral Infection
Fig. 4. (A) Pericentral pericellular fibrosis characterized by wire-like
bands of collagen radiating from the terminal hepatic venule along the space
of Disse (Masson trichrome stain). (B) Reticulin stain highlights a dense band
of mature collagen filling up the space of Disse (between arrows) and compressing
adjacent hepatocytes. (C) Hematoxylin-eosin stain demonstrating centrilobular
necroinflammatory activity and endothelialitis (immunohistochemical stain for
cytokeratins [monoclonal antibody clone AE1] specific for bile duct epithelium
was negative in this area). (D) Trichrome stain of the same field shown in (C)
demonstrates delicate bands of collagen extending from the venule into the lobule
along the space of Disse.
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