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table 3. Features
of Variant Syndromes Compared With Definite Autoimmune
Hepatitis
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|
AIH + PBC (n = 15) |
AIH + PSC (n = 14) |
Autoimmune Cholangitis (n = 11) |
Definite AIH (n = 87) |
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| Age (yr) |
52 ± 4 |
42 ± 4 |
44 ± 3 |
44 ± 2 |
| Men/women |
2/13 |
5/9 |
2/9 |
12/75 |
AST (reference value,  31 U/L) |
565 ± 159 |
232 ± 86 |
237 ± 122## |
519 ± 38 ,## |
| Bilirubin (reference value, 1.1 mg/dL) |
6.4 ± 2 |
2.2 ± 0.5 |
2.8 ± 1.3 |
3.9 ± 0.5 |
| Alkaline phosphatase (reference value,
309 U/L) |
433 ± 68 |
843 ± 161* |
1045 ± 2442 |
360 ± 26*, |
 -Globulin (reference value, 0.7-1.7 g/dL) |
3.3 ± 0.2 |
2.5 ± 0.3** |
1.74 ± 0.231.gif) |
3.6 ± 0.1,** |
| Immunoglobulin G (reference value, 700-1500 mg/dL) |
2751 ± 222§§§ |
2470 ± 330¶¶ |
1596 ± 1954§ |
3421 ± 132§,¶¶,§§§ |
| Immunoglobulin M (reference value, 60-300 mg/dL) |
527 ± 107 |
232 ± 22 |
198 ± 30 |
278 ± 0.2 |
SMA  1:40 |
10 (67).gif) |
6/13 (46) |
5 (45)§§ |
78 (90),§§, |
ANA  1:40 |
10 (67) |
6 (43)*** |
10 (91) |
66 (76)*** |
| DR4+ |
9 (60) |
2 (14) |
3/10 (30) |
42 (48) |
| DR3+ |
5 (33) |
10 (71) |
4/10 (40) |
43 (49) |
| Total score |
14.5 ± 0.8 |
14.2 ± 1¶ |
10.4 ± 0.9# |
18.5 ± 0.2,¶,# |
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NOTE. Numbers in parentheses are
percentages.
Abbreviation: AIH, autoimmune hepatitis.
Significantly different from each other at levels of *,.gif) .gif) ,,§,, ¶,#P < .0001, **P = .0002, P = .0006, P = .0007, §§P = .001, ,¶¶P = .006, ## ,***,P = .02, P = .03, and §§§P = .04. |
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