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New Model Allows Testing of Hepatitis C Treatments
'This is the first efficient and consistent model system for HCV to be developed,' Martina Buck, assistant professor of medicine at the University of California, San Diego, School of Medicine, who developed the culture, said in a university news release.

Natalie Cole Says She Has Hepatitis C
NEW YORK (AP) - Grammy-winning singer Natalie Cole has been diagnosed with hepatitis C, her publicist said in a statement Wednesday. Hepatitis C is a liver disease spread through contact with infected blood. The statement said the disease was revealed

Natalie Cole says she has hepatitis C (07/17/2008)
Grammy-winning singer Natalie Cole has been diagnosed with hepatitis C, her publicist said in a statement yesterday. Hepatitis C is a liver disease spread through contact with infected blood. The statement said the disease was revealed during a routine

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Hep C and Fatty Liver Disease Linked by Enzyme
Pittsburgh researchers have found that an enzyme known to participate in fat production is elevated in those with Hepatitis C. Further exploration of this enzyme could help physicians better predict which HCV patients are at risk of developing fatty liver...

ANA773 Resumes Race Against Hepatitis C
By reducing the dosing schedule in half, Anadys Pharmaceuticals returns to their investigation of ANA773, a Toll-Like Receptor-7 agonist prodrug. Approaching the Hepatitis C virus differently from most other contenders, Phase I clinical trials evaluating the safety, tolerability and viral-load...

Popular Illegal Drug Extra Harmful with HCV
Although scores of Americans are turning to the street drug methamphetamine to keep them awake and thin, scientists have found that it worsens Hepatitis C infection in two worrisome ways....

Frequency and Nature of the Variant Syndromes of Autoimmune Liver Disease

table  1.   Modified Scoring System for the Diagnosis of Autoimmune Hepatitis


Category Factor Score Category Factor Score

Sex Female +2 Alcohol <25 g/d >40 g/d 0 -2
Alk Phos:AST ratio  >= 3 <3 -2 +2 Immune disease Patient or relative +1
 gamma -Globulin or IgG levels above normal >2.0 1.5-2.0 1.0-1.5 <1.0 +3 +2 +1 0  Histological features Interface and acinar hepatitis with bridging Interface hepatitis Rosettes Plasma cells Biliary changes Other features +3 +2 +1 +1 1 -3
ANA, SMA, or anti-LKM1 titers >1:80 1:80 1:40 <1:40 +3 +2 +1 0 
AMA Positive  -2 Blood transfusion   or drugs Yes No -2 +1
Viral markers HBsAg   -3
IgM anti-HAV   -3
HCV RNA -3 Pretreatment score
Other viruses  -3   Definite diagnosis >15
Anti-HCV  -2   Probable diagnosis 10-15
All negative +3   Nondiagnostic <10
HLA DR3 or DR4 +1

Abbreviations: Alk Phos:AST ratio, ratio of serum elevations above reference value of alkaline phosphatase and aspartate transaminase; IgG, serum immunoglobulin G level; HBsAg, hepatitis B surface antigen; IgM anti-HAV, immunoglobulin M antibodies to hepatitis A virus.

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Updated 19 Jul 2008